Effects of microgravity on rat muscle

It is well known that humans exposed to long term spaceflight experience undesirable progressive muscle weakness and increased fatigability. This problem has prompted the implementation of inflight exercise programs because most investigators believe that the major cause of diminished muscle performance is a combination of disuse and decreased workload. Inflight exercise has improved muscle health, but deficits have persisted, indicating that either the regimens utilized were suboptimal or there existed additional debilitating factors which were not remedied by exercise. Clarification of this question requires an improved understanding of the cellular and molecular basis of spaceflight-induced muscle deterioration. To this end, multiple investigations have been performed on the muscles from rats orbited 5 to 22 days in Cosmos biosatellites and Spacelab-3 (2,4,5,8,10 to 14,16,18,19,21 to 23,25,27,28). The eight Cosmos 1887 investigations examined the structural and biochemical changes in skeletal and cardiac muscles of rats exposed to microgravity for 12.5 days and returned to terrestrial gravity 2.3 days before tissues were collected. Even though interpretation of these results was complicated by the combination of inflight and postflight induced alterations, the consensus is that there is marked heterogeneity in both degree and type of responses from the whole muscle level down to the molecular level. Collectively, the muscle investigations of Cosmos 1887 clearly illustrate the wide diversity of muscle tissue responses to spaceflight. Judging from the summary report of this mission, heterogeneity of responses is not unique to muscle tissue. Elucidating the mechanism underlying this heterogeneity holds the key to explaining adaptation of the organism to prolonged spaceflight

The role of proteases in pathologies of the synovial joint

Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation. Pathologies of the synovial joint are an important cause of patient morbidity and can affect each of the constituent tissues. A common feature of these pathologies is degenerative changes in the structure of the tissue which is mediated, at least in part, by proteolytic activity. Most tissues of the synovial joint are composed primarily of extracellular matrix and key pathological roles in the degeneration of this matrix are performed by metalloproteinases such as matrix metallproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS). However, other proteases such as cathepsin K are likely to play an important role, especially in bone turnover. In addition to the cleavage of structural proteins, proteolytic activities are employed to regulate the activity of other proteases, growth factors, cytokines and other inflammatory mediators. Proteases combine to form complex regulatory networks, the correct functioning of which is required for tissue homeostasis and the imbalance of which may be a feature of pathology. A precise understanding of the proteases involved in these networks is required for a true understanding of the associated pathology

Speech Recognition by Composition of Weighted Finite Automata

We present a general framework based on weighted finite automata and weighted finite-state transducers for describing and implementing speech recognizers. The framework allows us to represent uniformly the information sources and data structures used in recognition, including context-dependent units, pronunciation dictionaries, language models and lattices. Furthermore, general but efficient algorithms can used for combining information sources in actual recognizers and for optimizing their application. In particular, a single composition algorithm is used both to combine in advance information sources such as language models and dictionaries, and to combine acoustic observations and information sources dynamically during recognition.Comment: 24 pages, uses psfig.st

A note on leapfrogging vortex rings

In this paper we provide examples, by numerical simulation using the Navier-Stokes equations for axisymmetric laminar flow, of the 'leapfrogging' motion of two, initially identical, vortex rings which share a common axis of symmetry. We show that the number of clear passes that each ring makes through the other increases with Reynolds number, and that as long as the configuration remains stable the two rings ultimately merge to form a single vortex ring

Innovative Opportunities for Elementary and Middle School Teachers to Maintain Currency in Mathematics and Science: A Community College-School System Partnership

Since 1992 the Manassas Campus of Northern Virginia Community College – in response to requests from local school systems – has developed four innovative methods of assisting elementary, secondary and middle school teachers to enhance their content knowledge in science and mathematics, as well as integrate curriculum units for classroom presentation. These methods are based on the assumptions that: - While teachers at this level have fundamental understanding of math and science, if they wish to incorporate new concepts or technologies from these fields, graduate level content courses are generally beyond their background level. - Community College faculty can often provide a bridge that connects advanced content in science and mathematics with the applications that can be adapted to elementary/middle school curriculum. - Presenting content to a mixed audience of teachers from K-8 allows teachers to see how content can be adapted to grade levels above and below. - Content delivery methods must be interactive and must be responsive to the multiple demands on these teachers’ time. This requires flexibility in scheduling and course requirements

Comparison of Hedging Cost with Other Variable Input Costs

Recent spikes in commodity prices have led to higher margin amounts and option premiums. For the most part, producers have always attributed their lack of use in reducing risk via futures and options markets to the high cost associated with the use of these markets. This study determines the relative costs of hedging with futures and options and compares these with the costs of other variable inputs. We find that with the exception of hedging corn with both tools and soybeans with options the costs of hedging has only increased at roughly the same rate as all other inputs.Hedging costs, Costs of production, Risk management, Agribusiness, Agricultural Finance, Demand and Price Analysis, Farm Management, Marketing, Risk and Uncertainty,

Producer Perceptions of Corn, Soybean and Cotton Price Risk

Risk is an inevitable part of agricultural production and all producers face various forms of risk. This study used the subjective price expectations and price distributions of survey participants to determine how producer’s expectations compare with that of the market. Data used for this study were gathered through survey responses from Mississippi State University Extension meeting and workshop participants. Individual respondent’s discreet stated price and price distribution information was fitted to a continuous distribution and an implied mean and standard deviation was determined. This was compared to market price and price risk data. Participants largely over-estimated price. Individual volatilities resulting from each fitted distribution were lower than that implied by the market.price risk, price perception, subjective probability elicitation, Production Economics, Q13,

Simulation of gemini-agena docking

Attitude and translation control using visual docking simulator for Gemini/Agena projec

Power law burst and inter-burst interval distributions in the solar wind: turbulence or dissipative SOC ?

We calculate for the first time the probability density functions (PDFs) P of burst energy e, duration T and inter-burst interval tau for a known turbulent system in nature. Bursts in the earth-sun component of the Poynting flux at 1 AU in the solar wind were measured using the MFI and SWE experiments on the NASA WIND spacecraft. We find P(e) and P(T) to be power laws, consistent with self-organised criticality (SOC). We find also a power law form for P(tau) that distinguishes this turbulent cascade from the exponential P(tau) of ideal SOC, but not from some other SOC-like sandpile models. We discuss the implications for the relation between SOC and turbulence.Comment: 3 pages, 1 figure. Submitted to PRL on 25th February 2000. Revised version re-submitted on 9th May 2000. Second revised version submitted Phys. Rev. E on 26th June, 200